DAPAGLIFLOZIN BASE
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
CAS: 461432-26-8
Molecular Formula: C21H25ClO6
DAPAGLIFLOZIN BASE - Names and Identifiers
| Name | (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| Synonyms | Daglican BMS-512148 Dapagliflozi BMS-512148-05 Dapagliflozin DAPAGLIFLOZIN DAPAGLIFLOZIN BASE Dapagliflozin propanediol Dapagliflozin S1548 Selleck (1S)-1,5-anhydro-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
| CAS | 461432-26-8 |
| EINECS | 639-683-0 |
| InChI | InChI=1/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1 |
DAPAGLIFLOZIN BASE - Physico-chemical Properties
| Molecular Formula | C21H25ClO6 |
| Molar Mass | 408.88 |
| Density | 1.349 |
| Melting Point | 55-58°C |
| Boling Point | 609.0±55.0 °C(Predicted) |
| Flash Point | 322.139°C |
| Solubility | DMSO : ≥ 100 mg/mL (244.58 mM) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to off-white (Solid) |
| Color | White to Pale Yellow |
| pKa | 13.23±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.614 |
| MDL | MFCD13182359 |
DAPAGLIFLOZIN BASE - Introduction
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a drug, its chemical name is N-methyl-N'-nitrourea (N-Methyl-N).
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a white crystalline solid, soluble in water and some organic solvents. It has a strong smell of rotten eggs. (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is unstable under high temperature and bright light.
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is mainly used as a pesticide to control various pests, including insects, fungi and weeds. It can act as a pesticide by blocking the nerve conduction system of pests. In addition,(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol can also be used as a precursor for explosive substances, for example in the preparation of gunpowder.
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4, the preparation method of 5-triol is mainly prepared by methylated nitraminourea. First, nitramine urea is reacted with a methylating agent such as methine amine oxide to give N-methylnitramine urea. Then, the nitrification reaction of N-methyl nitrosamide urea is carried out, and nitric acid and sulfuric acid are added to make it Nitro, and the final (2S,3R,4R,5S,6R) is obtained. -2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol product.
About (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4, for the safety information of 5-triol, please pay attention to the following points:
- (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a strong oxidizer and avoids contact with combustibles and flammable materials.
-in the operation to maintain good ventilation, avoid the inhalation of gas or dust.
-avoid contact and reaction with strong acid, alkali and other substances.
- (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol may be toxic to aquatic organisms and should be avoided.
-tetrahydro-2H-pyran-3 using or handling (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl), 4, when using 5-triol, wear appropriate personal protective equipment, such as gloves, protective glasses and protective face masks.
Note that (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3, 5-triol is a dangerous chemical and must be used under the guidance of a laboratory or professional.
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a white crystalline solid, soluble in water and some organic solvents. It has a strong smell of rotten eggs. (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is unstable under high temperature and bright light.
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is mainly used as a pesticide to control various pests, including insects, fungi and weeds. It can act as a pesticide by blocking the nerve conduction system of pests. In addition,(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol can also be used as a precursor for explosive substances, for example in the preparation of gunpowder.
(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4, the preparation method of 5-triol is mainly prepared by methylated nitraminourea. First, nitramine urea is reacted with a methylating agent such as methine amine oxide to give N-methylnitramine urea. Then, the nitrification reaction of N-methyl nitrosamide urea is carried out, and nitric acid and sulfuric acid are added to make it Nitro, and the final (2S,3R,4R,5S,6R) is obtained. -2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol product.
About (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzene) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4, for the safety information of 5-triol, please pay attention to the following points:
- (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a strong oxidizer and avoids contact with combustibles and flammable materials.
-in the operation to maintain good ventilation, avoid the inhalation of gas or dust.
-avoid contact and reaction with strong acid, alkali and other substances.
- (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol may be toxic to aquatic organisms and should be avoided.
-tetrahydro-2H-pyran-3 using or handling (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl), 4, when using 5-triol, wear appropriate personal protective equipment, such as gloves, protective glasses and protective face masks.
Note that (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxyphenyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3, 5-triol is a dangerous chemical and must be used under the guidance of a laboratory or professional.
Last Update：2024-04-09 21:01:54
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